NAI-Acne

Fabbretti A, He CG, Gaspari E, Maffioli S, Brandi L, Spurio R, Sosio M, Jabes D, Donadio S. (2015) A derivative of the thiopeptide GE2270A highly selective against Propionibacterium acnes Antimicrobial Agents and Chemotherapy , 59(8): 4560-4568.


NAI-107 (and related lantibiotics)

Ortega MA, Hao Y, Walker MC, Donadio S, Sosio M, Nair SK, van der Donk WA. (2017) Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis Cell Chem. Biol.

Maffioli SI, Monciardini P, Catacchio B, Mazzetti C, Munch D, Brunati C, Sahl HG, Donadio S. (2015) Family of Class I Lantibiotics from Actinomycetes and Improvement of Their Antibacterial Activities ACS Chemical Biology, 10(4), 1034-1042.

Cruz JS, Iorio M, Monciardini P, Simone M, Brunati C, Gaspari E, Maffioli SI, Wellington E, Sosio M, Donadio S. (2015) Brominated Variant of the Lantibiotic NAI-107 with Enhanced Antibacterial Potency J. Nat. Prod. 78(11): 2642-2647.

Münch D, Müller A, Schneider T, Kohl B, Wenzel M, Bandow JE, Maffioli S, Sosio M, Donadio S, Wimmer R. Sahl HG.(2014) The lantibiotic NAI-107 binds to bactoprenol bound cell wall precursors and impairs membrane functions J. Biol. Chem.  289(17): 12063-76.

Sosio M, Gallo G, Pozzi R, Serina S, Monciardini P, Bera A, Stegmann E, Weber T. (2014) Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107. Genome Announc. 23;2(1). pii: e01198-13.

Maffioli SI, Iorio M, Sosio M, Monciardini P, Gaspari E, Donadio S. (2014) Characterization of the congeners in the lantibiotic NAI-107 complex J. Nat. Prod. 77(1):79-84.

Jabés D, Brunati C, Candiani G, Riva S, Romanó G, Donadio S. (2011) Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens Antimicrob. Agents Chemother. 55:1671-6.


NAI-603

Jabes D, Brunati C, Candiani G, Riva S, Romanó G, Maffioli S, Rossi R, Simone M, Gaspari E, Donadio S. (2014) Pharmacological Properties of NAI-603, a Well-Tolerated Semisynthetic Derivative of Ramoplanin Antimicrob. Agents Chemother. 58:1922-1929.


NAI-112

Iorio M, Sasso O, Maffioli SI, Bertorelli R, Monciardini P, Sosio M, Bonezzi F, Summa M, Brunati C, Bordoni R, Corti G, Tarozzo G, Piomelli D, Reggiani A, Donadio S. (2014) A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity ACS Chem. Biol. 9:398-404.


PUM

Maffioli SI, Zhang Y, Degen D, Carzaniga T, Del Gatto G, Serina S, Monciardini P, Mazzetti C, Guglierame P, Candiani G, Chiriac AI, Facchetti G, Kaltofen P, Sahl HG, Dehò G, Donadio S, Ebright RH. (2017) Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase Cell 169(7) 1240-1248.


Microorganisms and molecules

Iorio M, Cruz J, Simone M, Bernasconi A, Brunati C, Sosio M, Donadio S, Maffioli SI. (2017) Antibacterial Paramagnetic Quinones from Actinoallomurus  DOI: 10.1021/acs.jnatprod.6b00654

Cruz JC, Maffioli SI, Bernasconi A, Brunati C, Gaspari E, Sosio M, Wellington E, Donadio S. (2017) Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus J Antibiot (Tokyo). 70(1):73-78.

Tocchetti A, Bordoni R, Gallo G, Petiti L, Corti G, Alt S, Cruz JCS, Salzano AM, Scaloni A, Puglia AM, De Bellis G, Peano C, Donadio S, Sosio M. (2015) A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete PLos ONE 10(7)

Maffioli SI, Cruz JCS, Monciardini P, Sosio M, Donadio S. (2016) Advancing cell wall inhibitors towards clinical applications J. Ind. Microbiol. Biotechnol. 43: 177-184.

Monciardini P, Iorio M, Maffioli S, Sosio M and Donadio S. (2014) Discovering new bioactive molecules from microbial sources Microbial Biotechnology, 7(3), 209-220.

Zhang Y, Degen D, Ho MX, Sineva E, Ebright KY, Ebright YW, Mekler V, Vahedian-Mohaved H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E and Ebright RH. (2014) GE23077 binds to the RNA polymerase "I" and "I+1" sites and prevents the binding of initiating nucleotides eLife, DOI: 10.7554/eLife.02450.

Tocchetti A, Maffioli S, Iorio M, Alt S, Mazzei E, Brunati C, Sosio M, Donadio S. (2013) Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270 Chem. & Biol. 20:1067-77.

Maffioli SI, Fabbretti A, Brandi L, Savelsbergh A, Monciardini P, Abbondi M, Rossi R, Donadio S, Gualerzi CO. (2013) Orthoformimycin, a selective inhibitor of bacterial translation elongation from Streptomyces containing an unusual orthoformate ACS Chem. Biol. 8:1939-46.

Simone M, Monciardini P, Gaspari E, Donadio S, Maffioli SI. (2013) Isolation and characterization of NAI-802, a new lantibiotic produced by two different Actinoplanes strains J. Antibiot. 66:73-8.

Mazzetti C, Ornaghi M, Gaspari E, Parapini S, Maffioli S, Sosio M, Donadio S. (2012) Halogenated spirotetronates from Actinoallomurus J. Nat. Prod. 75:1044-50.

Pozzi R, Simone M, Mazzetti C, Maffioli S, Monciardini P, Cavaletti L, Bamonte R, Sosio M, Donadio S. (2011) The genus Actinoallomurus and some of its metabolites  J. Antibiot. 64:133-9.

Recent publications